What is depression?

Although it is natural for everyone to go through times when they feel sad or unhappy for a few days, this does not always mean that they have depression.

Depression is a medical word that is used to describe a low mood that lasts for a long time. It has a range of different symptoms that can affect everybody differently. It can change how you think, how you feel, and your ability to get on with normal daily activities.

Depression can range from mild to severe, and is thought to affect 1 in 10 people throughout their lives.

Depressed young girl crying at her table.


What are the symptoms of depression?

There are many different ways in which someone can feel depressed. People may have only a few symptoms of depression, or many symptoms at once.

It isn’t always possible to tell that you’re having symptoms of depression straight away, because they can take some time to develop. Many people try to cope with their symptoms without realising that they are unwell. It is often a family member or a friend who suggests that something could be wrong.

Symptoms of depression are split into the following categories:

Psychological symptoms are symptoms that are felt in the mind. Examples of these symptoms include:

  • Continuous low mood
  • Feeling hopeless
  • Feeling helpless
  • Low self-esteem
  • Feeling tearful
  • Feeling guilty
  • Feeling irritable
  • Feeling worried or anxious
  • Lack of interest in doing things
  • Lacking motivation
  • No longer enjoying the things in life that you used to
  • Having thoughts of harming yourself
  • Having thoughts of ending your life

Physical symptoms are symptoms that are experienced in the body. Examples of these symptoms include:

  • Moving or speaking more slowly than is normal for you
  • Changes in appetite
  • Changes in weight
  • Body aches and pains
  • Lack of energy
  • Constipation
  • Loss of interest in sex 
  • Changes to your periods
  • Waking up very early in the morning
  • Struggling to get to sleep

Social symptoms are symptoms that affect how you behave. Examples of these symptoms include:

  • Not wanting to see your friends/family as much as you used to
  • Feeling alone and isolated
  • Struggling to function at work/home

What is psychosis?

If you have very severe depression, you may also experience something called psychosis. This can be an extremely frightening and upsetting experience and may include developing the following symptoms:

  • Delusions e.g. being convinced that someone is trying to harm you, or that you have done something terrible.

  • Hallucinations e.g. hearing voices or seeing things that are not there.

Even though these things are not actually happening, they feel extremely real to the person going through them. This can make it really hard to understand that they are also a symptom of your depression and that you need help to get better.


Can you get anxiety and depression together?

It is also very common to have depression and anxiety together as some of the symptoms of these conditions can overlap. For example:

  • Feeling very worried about your low mood
  • Feeling restless or fidgety
  • Struggling to eat
  • Reduced appetite
  • Being agitated or irritated quickly
A woman with agoraphobia looking sad and gazing outside of her window.


When some people are feeling low, they may feel that harming themselves will help them cope with their feelings. Although doing this might give you a sense of relief in the very short term, it is very dangerous and can make you feel so much worse in the long term.

Suicidal thoughts

If you’re feeling very low and see no hope in the future, you may often find yourself thinking that things would be better if you were no longer here.

These thoughts can be very scary, and you may think that things would be better if you were dead, or you may even begin to plan how you might end your life. These thoughts can feel like they are always there and controlling you, which can be really frightening. If you are having these thoughts, it is incredibly important that you try to find help as soon as possible. 

If you are thinking of ending your life, this is an emergency and you should find help straight away.

Please call 115 AS SOON AS POSSIBLE if you are having suicidal thoughts.

Is depression contagious?

No, depression is not contagious. It cannot be passed from person to person.

However, spending a lot of time with someone who is depressed, and trying to care for them, can be really demanding and hard. It can have a knock on effect on your own mood, and can also make you to feel down as well. If you are feeling like this may be happening to you, it is best to speak to your doctor, who can assess you in more detail.

Can depression kill you?

Depression cannot kill you in the traditional way that a serious infection or cancer might, but it can increase your risk of death.

For the majority of people, their depression will be treated successfully and be kept under control, allowing them to continue enjoying their life. In some cases however, people who have very severe depression, or those do not seek help for their depression at all, may end up taking their own life.

In addition to a higher risk of suicide, people who suffer from depression may find it more difficult to seek help for or manage their physical health issues. This therefore puts them at greater risk of dying from them.


What are the different types of depression?

There are many different types of depression. These include:

Many people have heard the term ‘clinical depression’. This just simply means that a doctor has given you a diagnosis of depression based on your symptoms. It does not necessarily mean that your depression is more severe if you have clinical depression, it just means that it has been recognised by a doctor.


Female doctor talking to a female patient in her office.

This is the name that doctors give to describe your time of depression when they make a diagnosis. They might say that you are going through a ‘depressive episode’.

Man sitting on the couch holding his head, struggling with depression.

Your depressive episode might be described to you as mild, moderate or severe.

Grading your depression as mild, moderate or severe, is a way of describing how much of an effect your symptoms are having on your daily life. This grading system normally helps doctors decide what types of treatment you should be offered.

Mild depression

Mild depression has some impact on daily life, but most people can continue to function well.

Moderate depression

Moderate depression has quite a big impact on daily life, such as at home or with work/school. For example, having moderate depression may mean that:

  • you do not carry out your work as well as you used to 
  • you struggle to concentrate at school
  • you struggle to motivate yourself to meet deadlines

Severe depression

Severe depression makes it almost impossible to get through daily life, and carrying out simple tasks can become very difficult. It can also cause working or personal relationships to  break down.

Recurrent depressive disorder


Some people only have one ‘depressive episode’ during their lifetime, with their mood fully recovering afterwards. However, in some cases:

  •  50% of people will go on to have another time in their life when their mood is low.
  • 60% of people will go on to have a third (or more) episode of low mood.

Having more than one ‘depressive episode’ is called recurrent depressive disorder. Women are twice as likely to have recurrent depressive disorder than men.

Dysthymia is also called persistent depressive disorder or chronic depression. Your doctor might tell you that you have dysthymia if you have felt low for over 2 years.

People with dysthymia tend to go through a longer period of mild depression. They often go to see their doctor complaining about a long-standing feeling of tiredness and a lack of interest in doing things. They can also have a more severe depressive episode, but not return back to their normal mood afterwards.

If your low mood is linked to a particular recent stressful event in your life, then your doctor may call this reactive depression. The stressful event could be things like:

  • A divorce
  • Losing a job
  • A break up 
  • Money worries

Reactive depression can cause a lot of stress, and can make  people feel down for a long period of time.

Seasonal affective disorder (SAD) is a mental health condition that is brought on by the change in seasons.


Seasonal Affective Disorder

Generally, a person with SAD begins to feel depressed during the winter months of the year when there is less sunlight. They then start to feel better again in the spring and summer months. This tends to happen every year.

As it can happen every winter, it can also be considered as a recurrent depressive disorder.

Psychotic depression is sometimes seen in people with more severe depression. If you have severe depression, you probably feel extremely sad and low for most of the day, everyday. You may also have no interest in doing anything. Even completing the most simple task can feel impossible. 

Some people with this level of depression may also start to develop a condition called psychosis. Having psychosis alongside depression means that you also experience either delusions or hallucinations.

gaia medical


What are delusions?

Delusions are strong, unshakable beliefs about something that isn’t true.

What are hallucinations?

Hallucinations are hearing, feeling, smelling, seeing or tasting something that is not there. 

These delusions or hallucinations are often something negative about oneself. For example, thinking you have committed a terrible crime, or feeling like you have an illness. 

People with psychotic depression are more likely to have thoughts about harming themselves or others, and are more likely to think about ending their own life.

Postnatal depression, also called postpartum depression, is depression that happens in the first 12 months after a woman gives birth. It is more than just baby blues, which is when women can feel anxious, sad and teary in the two weeks after delivery. 

Woman with postnatal depression sitting in a corner sad with a baby behind her.


Postnatal depression can happen at any time in the first year after giving birth. It can be difficult to recognise, as it often starts gradually. Signs that you could have postnatal depression include:

  • Feeling sad for a long period of time
  • Feeling worried or scared
  • No longer enjoying or being interested in things that you used to do
  • Feeling exhausted all the time
  • Having trouble falling asleep at night
  • Finding it hard to bond with your baby
  • Not wanting to be in contact with other people
  • Finding it hard to concentrate

Can men get postnatal depression?


It’s important to note that having a baby can be a huge life change for many people. More recently men suffering from postnatal depression has been discussed too. Men feeling very low after the birth of a child should take it seriously and see their doctor to discuss their symptoms further.

What is postpartum psychosis?


In the most severe cases, women with postnatal depression can also have psychosis. This is often called postpartum psychosis.  It occurs in around 0.1% of women who have given birth, and it is more common in women with pre-existing mental health problems.

Postpartum psychosis is most likely to happen in the first four weeks after a woman gives birth, and it is extremely serious. The mother can experience delusions or hallucinations in relation to her baby, putting her baby at risk. For example, she may hear voices telling her to hurt her baby or herself, or believe that someone is trying to harm them both.

Although bipolar disorder is a different mental health condition to depression, it is important to know about because someone with bipolar disorder can have symptoms of feeling extremely low for a long period of time. This is called bipolar depression or manic depression.

Someone with bipolar disorder can also have periods of time with extreme behaviour, which are known as high’s or mania. If you see a doctor about low mood, they may also ask you about extreme highs to check if you may have bipolar disorder.

What causes depression?

Everyone is completely different. It can be a combination of things that can cause people to feel low. Some people may even feel depressed for no specific reason that they can think of.

Serious events that happen in your life can often be a trigger for depression:

  • Moving house
  • Bereavement
  • Losing your job
  • Separation or divorce
  • Assault (physical or sexual)
  • Bullying
  • Becoming pregnant or having a baby
  • Money problems

Suffering with a long-term health condition can increase your risk of getting depression. In particular, people with the following medical conditions have been seen to have an increased risk:

  • Medical conditions that have an affect on the brain like Parkinson’s disease, dementia or a brain injury
  • Vitamins – if you’re low in vitamins such as B12, it will increase your risk of developing depression
  • Thyroid disease – having problems with your thyroid gland can increase your risk of becoming depressed
  • Hormonal changes – Menopause/childbirth
  • Long term conditions that cause pain such as rheumatoid arthritis, or back pain
  • Cancer
  • Anxiety
  • PTSD (Post-Traumatic Stress Disorder)
  • Eating disorders

Research has shown that going through something traumatic or difficult in childhood can increase your risk of suffering with depression in adulthood.

  • Abuse (physical, sexual or emotional)
  • When someone close to you has died
  • Parents divorcing
  • Family accidents
  • Neglect
  • Trauma

Drinking excess alcohol and taking illicit drugs have both been linked to a higher risk of depression. Those suffering from depression also have higher rates of drug and alcohol misuse, as some people use them to self-medicate their symptoms. These substances actually worsen depression and should be avoided. Your doctor will be able to help you if you are concerned about drug or alcohol use.

Some prescription medications can also contribute to the development of depression. If you are taking a medicine and think it could be causing you to have a low mood, please speak to your doctor about it.

Research has shown that if you are surrounded by a difficult environment growing up, then it can have an impact on your mood later in life. This includes:

  • Living in an area of conflict
  • Living in poverty
  • Having a lower level of education

There has been a lot of research in brain chemicals called ‘neurotransmitters’ and how they are involved in causing depression. However, the way in which they might do that is still poorly understood. 

Often, if you cannot link your depression to a specific life event, your doctor may say that you have a ‘chemical imbalance’ in the brain. The three main chemicals they are referring to are:

  • Serotonin
  • Noradrenaline
  • Dopamine

Some research suggests that having too little of a specific chemical in your brain can lead to depression. In reality however, it is probably much more complicated than this, which is why researchers cannot say for sure at the moment how this process works.

Having someone else in your family who suffers, or has had depression, may make it more likely for you to get depression.

Who usually gets depression?

Depression can really affect anyone of any age, but it often starts in adulthood.

Depression in children


Until recently, children having low mood and getting depressed wasn’t really talked about. However, more recently it is being recognised as an increasing problem in children. Research shows that children suffer with anxiety before going onto experiencing low mood and depression. They can also complain of physical problems like headaches and stomach aches. 

Children having problems at school, being unable to concentrate or being disruptive may also be a sign of depression. In childhood, boys and girls are affected equally. 

Depression in children can be caused by a combination of things, or even nothing specific at all. Generally things that increase the risk of a child suffering with depression include:

  • Difficulties at home such as parents separating
  • Moving house
  • Bereavement 
  • Bullying
  • Abuse (verbal, physical, psychological, neglect, sexual)


Depression in teenagers


As children become teenagers, girls are twice as likely to be depressed as boys. Going through puberty can be difficult, and teenagers begin to become more aware of things happening around them. 

Symptoms of depression in teenagers are very similar to those in adulthood, and are most likely to be caused by a stressful life event. 

Teenagers can go onto to develop other more serious problems as a result of their depression, such as:

  • Self-harming 
  • Self-neglect
  • Misusing drugs and alcohol 
  • Suicide

It is important that depression in children and teenagers is recognised early, and that help is given to try and treat it.

Depression in women


Women are more likely to be diagnosed with depression than men. There are a few different factors that researchers have thought make women more vulnerable to depression:

  • Hormonal factors (menstrual cycle and menopause)
  • Reproductive events (pregnancy, infertility and miscarriage)
  • Medications (oral contraceptive pill and hormone replacement therapies)
  • Abuse (sexual, psychological, physical, verbal)
  • Lower social status
  • Increasing job related stress – some women may feel that there is increased pressure on them to be a good mother, perform well at work and keep on top of things at home. This can be extremely stressful and lead to low mood.

It may also be the case that more women are diagnosed with depression because it is more acceptable for women to talk about their feelings with family, friends or their doctor.

Depression in men


It is thought that men are less likely to suffer from depression than women. More recently, doctors have recognised that depression is actually a serious and underdiagnosed condition in men. 

It is thought that this could be because traditionally, men were not encouraged to talk about their feelings with others in order to appear more masculine. They are also less likely to visit their doctor complaining of low mood.

If you are a man experiencing low mood, it is really important that you seek help.

Recent research has shown that men do not necessarily experience depression less than women, but they can show their symptoms in a different way. This means that depression can be harder to recognise in men.

Symptoms of depression that men are more likely to have than the traditional low mood include:

  • Aggressive behaviour 
  • Violence towards others
  • Self-harm
  • Drug and alcohol misuse
  • Suicide

Depression in older people


Depression in older people is extremely common. It can be caused by a number of different things and can have a big impact on their health. 

As we get older, we are more likely to suffer with other health conditions such as high blood pressure or chronic pain. If an elderly person is also depressed, they may be less likely to take their medications, and less likely to engage with doctors and therapists to get better. 

Older people may also be more difficult to treat as they may take a lot of other medications which make it unsuitable to take antidepressants. Some of the causes of depression specifically linked to elderly people are:

  • Death of a spouse
  • Memory loss
  • Loneliness


How is depression diagnosed?

Depression is usually diagnosed by going to see your family doctor. If you experience the symptoms of depression for most of the day, every day for more than two weeks, then you should go to see your doctor.

It is especially important to go and see them if you feel like you are not getting better, or if you are having thoughts of harming yourself or others.

What will the doctor do when I go to see them?

Asking questions

They will usually start by asking you some questions about how your general health is and how you have been feeling.

Blood tests

They may suggest doing a blood test to rule out other medical conditions that could cause similar symptoms to depression, such as thyroid problems or low vitamin D levels.


Your doctor may also work with you to fill out a questionnaire to help show if your depression is mild, moderate or severe. They may also use a questionnaire to see if you also have symptoms of anxiety. 

Specialist referrals

If your doctor has any further questions about your diagnosis, or if they think that it may be another mental health condition, they may refer you to a specialist called a psychiatrist. This is a type of doctor who looks after people with mental health conditions. 

Psychiatrists may have access to different treatments or therapies that may be beneficial to you.

How can depression affect your quality of life?

Having depression can have a huge affect on your quality of life. It can affect so many different aspects of your life that it can seem that it is taking over. This is why it is important to seek help as soon as possible to try to manage your depression.

When depression is treated, the majority of people find that they can return to the old way of life they had before they started feeling low.

Untreated depression or people with moderate or severe depression find that their depression has a bigger effect on their quality of life. They may feel that it is taking over, or even ruining their life. For these people, it can be very difficult to function as normal without depression affecting their:

  • Sleep –  this may be sleeping for longer, struggling to get to sleep, waking up early or sleeping too much.

  • Relationships at home – with your partner or spouse, children or parents.

  • Relationships with work colleagues – meaning you are unable to progress as well at work.

  • Relationships with friends – this can often lead to a feeling of isolation.

  • School or work assignments – often people can lose interest or struggle to maintain their concentration on important tasks.

Which other conditions have similar symptoms to depression?

There are some conditions in which the low mood can look like depression, but actually has another cause. This is why it is important for your doctor to do a thorough assessment, so that they can exclude any other causes before giving a diagnosis of depression.

Hypothyroidism is a common cause of low mood in women especially. The thyroid gland is a gland found in the neck that produces hormones that have an effect on different parts of the body. 

If your thyroid begins to produce too little thyroid hormones, it can lead to a condition called hypothyroidism. One of the symptoms of hypothyroidism can be low mood. 

In most cases, a medication can be given to increase the levels of thyroid hormone in the body, meaning that the thyroid gland can go back to normal again. 

If you speak to your doctor about having symptoms of low mood, they may suggest doing a blood test to rule out hypothyroidism. 

Hypothyroidism can also cause the following symptoms:

  • Weight gain
  • Tiredness
  • Thinning hair
  • Dry skin
  • Constipation
  • Feeling the cold 
  • Slow heart rate

Vitamin D is needed to keep bones and muscles strong. The body can get vitamin D from fish and red meat, as well as sunlight.  People that stay inside, or are often covered up when they go outside, may not get enough vitamin D. 

Symptoms of low vitamin D levels include:

  • Fatigue
  • Low mood
  • Hair loss
  • Aches and pains
  • Slow wound healing

ADHD stands for attention-deficit hyperactivity disorder. If this has not been diagnosed as a child, it can sometimes be mistaken for depression in adulthood. There are a lot of symptoms that cross-over between depression and ADHD, but some symptoms that may be more in line with ADHD include:

  • Continually starting new tasks before finishing the old ones
  • Restlessness
  • Extreme impatience 
  • Excessive talking 
  • Appearing unable to listen

Grief is a very normal thing for people to go through after someone they love dies. Feeling extremely sad and being low in mood when someone dies is a natural experience that can last for a different amount of time, depending on the person. Grief can often come and go when you think of the person you lost.

Just because you remain sad about someone that has died for a long time, it does not necessarily mean that you are depressed. However, if you notice that you are experiencing other symptoms of depression such as worthlessness, hopelessness and persistent low mood, then you should speak to your doctor.

Dementia is a disorder of the brain which can cause memory loss, behavioural changes and low mood. Telling the difference between the early stages of dementia and depression in the elderly can be very difficult. They share a lot of the same symptoms, and often develop over a long period of time. Your doctor may ask you questions specifically to test your memory to try and distinguish between the two.

Premenstrual dysphoric disorder (PMDD) is often referred to as severe premenstrual syndrome. PMDD can affect up to 10% of women. It is a serious condition described by severe mood disturbances such as: 

  • Severe depression
  • Irritability
  • Anger
  • Suicidal thoughts
  • Physical symptoms (e.g. breast tenderness, and joint pain)

Unlike depression, the symptoms are only there at certain times within the menstrual cycle, often in the lead up to your period. It can be extremely distressing and have a real effect on your quality of life.



The information in this article is written for general information purposes only, and is not a substitute for professional medical advice, treatment or care. It is incredibly important that you do not make decisions regarding any symptoms based on this information alone. If you are worried about any symptoms you may be having, or have any further questions about this condition, please speak to a qualified and trustworthy medical professional.

How do you treat depression?

There are a number of different treatment options available that can help to treat depression. Your doctor can work with you to decide the best treatment plan for you.

If you have mild depression, you might make a decision with your doctor to not use any medical treatment. In this case, your doctor may recommend some lifestyle things that you can do at home instead. 

They may recommend:

  • Avoiding smoking – smoking has been linked to making depression worse.


  • Cutting down on alcohol – drinking a lot of alcohol has been linked to making depression worse.


  • Getting enough sleep – not getting enough sleep can make depressive symptoms worse.


  • Eating a well balanced diet – eating a lot of processed foods and not enough fruit, vegetables, fibre and protein can make your depression worse.


  • Talking to friends and family – having someone close to you to talk to about your feelings can really help your recovery.


  • Practising mindfulness – this is a technique involving taking time to relax and focuses on breathing techniques. It helps you focus on the present and not think about the past or the future. Many people find it very helpful.


  • Online support groups – it can be really useful to talk to other people going through similar experiences. 

If your doctor recommends these lifestyle changes, they will probably arrange a follow up appointment to reassess your mood again in a few weeks after trying them.

If your depression is more severe, or you want to start being treated immediately your doctor may recommend the following treatments:

  • Talking therapies
  • Medication  
  • A combination of the two

The most common type of talking therapies offered is Cognitive Behavioural Therapy (CBT). CBT is a type of talking treatment that tries to change your behaviour by focusing on your beliefs and thoughts, and how they affect your feelings and behaviour. This technique can help you make sense of overwhelming behaviours by breaking them down into smaller parts.

CBT helps to stop negative ways of thinking that can make you feel sad, and instead leads you to feel better about yourself. 

Ideally after doing CBT, you would have learnt some tools you can use in your mind that can help you break this cycle of negative thinking in the future. 

CBT can come many forms, such as:

  • Self-help material such as books or leaflets
  • Online CBT program to take place over a number of weeks
  • Phone CBT sessions with a therapist
  • Group CBT sessions
  • Individual CBT sessions

There can be other talking therapies available if your specific trigger for depression is trauma related. Please ask your doctor about these.

Depression Medications

Medications used to treat depression are called antidepressants.

For people beginning treatment with an antidepressant it is worth considering:

  • Antidepressants can take some time to work
  • Symptoms of depression may initially get worse
  • They can suffer with side effects
  • Antidepressants, once started, should be continued for at least 6 months, even if the person taking them starts to feel better before then

There are a few different types of antidepressants:

Selective serotonin reuptake inhibitors (SSRIs) are a type of antidepressant that work by increasing the amount of serotonin in the brain. Serotonin is one of the chemicals found in our brain that is linked with depression.

SSRIs are the most common type of antidepressant prescribed. Examples of SSRIs include:

  • Fluoxetine (Prozac®)
  • Sertraline (Zoloft®)
  • Paroxetine (Paxil®)
  • Escitalopram (Lexapro®) 
  • Citalopram (Celexa®)

Be patient when taking SSRIs

It can take at least 6 weeks to notice any changes after you start taking an SSRI, but they can be very effective when they do start working. 

If after a while of taking SSRIs you feel that they have had some effect, but that you still have low mood, your doctor may consider  increasing your dose. 

SSRIs are commonly used to treat depression as they are less likely to cause problems with other medications that you may be taking at the same time. If you are also taking anti-inflammatory painkillers (such as ibuprofen), your doctor may give you another medication to protect the lining of your stomach.

What are the side effects of SSRIs?

Some of the most common side effects of SSRIs are:

  • Agitation (feeling uneasy and restless)
  • Nausea (feeling or being sick) 
  • Constipation or diarrhoea 
  • Loss of appetite and weight loss
  • Dizziness
  • Blurred vision 
  • Dry mouth
  • Excessive sweating 
  • Headaches
  • Low sex drive and sexual problems
  • Difficulty sleeping

Serotonin and Noradrenaline Reuptake Inhibitors (SNRIs) are another type of antidepressant that can be prescribed for depression. The most common ones are:

  • Venlafaxine (Effexor®)  
  • Duloxetine (Cymbalta®)

What are the side effects of SNRIs?

Side effects usually happen in the first few weeks after treatment has started. Over time  your body gets used to the medications, and the side effects often go away. 

The most common side effects caused by SNRIs are:

  • Feeling sick (nausea)
  • Drowsiness 
  • Dry mouth 
  • Headaches
  • Dizziness
  • Constipation
  • Problems sleeping
  • Sweating or feeling very hot
  • High blood pressure

Tricyclic antidepressants (TCAs) are the oldest type of antidepressants, originally used in the 1950s. They work by increasing the amount of time that serotonin and noradrenaline stays in the brain.

It would be quite uncommon to use this medication these days, unless someone could not have, or did not tolerate using an SSRI or SNRI. 

Someone that may have been on a TCA for a long time and who responds well to it, might be advised to stay on it by their doctor to avoid withdrawal side effects of coming off it again. Anyone on a TCA should see their doctor regularly for check ups.

What are the side effects of TCAs?

They can can cause quite a lot of unpleasant side effects including:

  • Blurred vision
  • Confusion and agitation
  • Drowsiness
  • Dry mouth
  • Hallucinations
  • Trembling

Monoamine Oxidase inhibitors (MAOIs) are another type of antidepressant medication. They also make serotonin and noradrenaline last longer in the brain by stopping them from being broken down. 

They are not a common type of antidepressant and are often only used if you’ve tried all other types of antidepressants and they haven’t worked for you. 

They should only be prescribed by a specialist mental health doctor (psychiatrist).

Other treatment options

There are also some other treatment options available:

If your depression is very severe or you have made an attempt to take your own life, it may be recommended that you stay in a hospital bed while you are treated for your depression. 

This can be voluntary or, in some cases if you continue to be a danger to yourself by trying to harm yourself, it can be involuntary. 

Whilst you are in hospital, you will be given your regular medication and you will have mandatory talking therapy sessions to try and help you recover.

Depending on where you live or if you can afford to pay for it, there may be an option to attend a rehabilitation centre. 

These are places that people can go and stay when they’re depressed to undergo intense treatment such as talking therapies. These are mostly private facilities that cost a lot of money to attend.

Electroconvulsive therapy (ECT) is a treatment used less commonly these days. It is a procedure performed by a specialist doctor, and it tends to be used in patients who have severe depression and who have not responded well to any form of antidepressant medication.

How does ECT work?

A patient is put under general anaesthetic which makes them unconscious so that they do not hear, feel or see anything. Then, small electrical currents are passed through the brain to cause a seizure. 

It is thought that this technique changes the chemicals in the brain, which may help treat depression. It can be very successful if it is used on the right patient, and it can have quick results.


Is there a cure for depression?

Depression does not have a specific cure that can be used for everyone. However, it is a very treatable condition with a lot of treatment options available to try.

It is important to speak to your doctor about all the options available for you, and it is better to do this as early as possible. It may take some trial and error before you find the right treatment that works best for you.

Can you prevent depression?

Remember it is normal for everyone to feel sad or a bit low from time to time, so it is not something that can be prevented entirely. It is recommended that practicing some self-care can be a great way to try and prevent more prolonged periods of feeling low, and therefore depression. This can include:

  • Try to keep active
  • Talk to someone you trust
  • Mindfulness
  • Take time to do something you enjoy
  • Try and get lots of sleep
  • Eat a balanced diet
  • Look after your physical health
  • Do not suddenly stop taking any pre-existing medications

If you have been depressed in the past, it is worth being mindful of what your triggers were for that episode. Doing this could make you more aware if you start to feel low again in the future, and it can enable you to seek help as early as possible.

Is there a test or quiz I can take for depression?

We have created a short online test that can help you get a better understanding of your symptoms. You can take the test here.

Please be aware however, that this test does not give you a formal diagnosis, and does not replace a full assessment by a qualified mental health professional.

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  1. World Health Organization. Depression and other common mental disorders: global health estimates. World Health Organization; 2017. (Access here)
  2. Talarowska M, Zajączkowska M, Gałecki P. Cognitive functions in first-episode depression and recurrent depressive disorder. Psychiatria Danubina. 2015 Mar 9;27(1):0-43. (Access here)
  3. Cuijpers P, van Straten A, Schuurmans J, van Oppen P, Hollon SD, Andersson G. Psychotherapy for chronic major depression and dysthymia: a meta-analysis. Clinical psychology review. 2010 Feb 1;30(1):51-62. (Access here)
  4. Keller J, Schatzberg AF, Maj M. Current issues in the classification of psychotic major depression. Schizophrenia Bulletin. 2007 Jul 1;33(4):877-85. (Access here)
  5. Akiskal HS. Dysthymia: clinical and external validity. Acta Psychiatrica Scandinavica. 1994 Oct;89:19-23. (Access here)
  6. Partonen T, Lönnqvist J. Seasonal affective disorder. CNS drugs. 1998 Mar 1;9(3):203-12. (Access here)
  7. Manea L, Gilbody S, McMillan D. Optimal cut-off score for diagnosing depression with the Patient Health Questionnaire (PHQ-9): a meta-analysis. Cmaj. 2012 Feb 21;184(3):E191-6. (Access here)
  8. Anderson JE, Michalak EE, Lam RW. Depression in primary care: Tools for screening, diagnosis, and measuring response to treatment. British Columbia Medical Journal. 2002;44(8):415-9. (Access here)
  9. Vythilingam M, Chen J, Bremner JD, Mazure CM, Maciejewski PK, Nelson JC. Psychotic depression and mortality. American Journal of Psychiatry. 2003 Mar 1;160(3):574-6. (Access here)
  10. Lattuada E, Serretti A, Cusin C, Gasperini M, Smeraldi E. Symptomatologic analysis of psychotic and non-psychotic depression. Journal of Affective Disorders. 1999 Jul 1;54(1-2):183-7. (Access here)
  11. Sit D, Rothschild AJ, Wisner KL. A review of postpartum psychosis. Journal of women’s health. 2006 May 1;15(4):352-68. (Access here)
  12. Leigh B, Milgrom J. Risk factors for antenatal depression, postnatal depression and parenting stress. BMC psychiatry. 2008 Dec;8(1):24. (Access here)
  13. Spinelli MG. Postpartum psychosis: detection of risk and management. American Journal of Psychiatry. 2009 Apr;166(4):405-8. (Access here)
  14. Kessler RC, Bromet EJ. The epidemiology of depression across cultures. Annual review of public health. 2013 Mar 18;34:119-38. (Access here)
  15. Al-Hamzawi AO, Bruffaerts R, Bromet EJ, AlKhafaji AM, Kessler RC. The epidemiology of major depressive episode in the Iraqi general population. PloS one. 2015;10(7). (Access here)
  16. Huys QJ. Reinforcers and control: Towards a computational aetiology of depression. University of London, University College London (United Kingdom); 2007. (Access here)
  17. Monroe SM, Slavich GM, Gotlib IH. Life stress and family history for depression: The moderating role of past depressive episodes. Journal of psychiatric research. 2014 Feb 1;49:90-5. (Access here)
  18. Cicchetti D, Toth SL. The development of depression in children and adolescents. American psychologist. 1998 Feb;53(2):221. (Access here)
  19. Martin G. Depression in teenagers. Current therapeutics. 1996 Jun;37(6):57. (Access here)
  20. Noble RE. Depression in women. Metabolism. 2005 May 1;54(5):49-52. (Access here)
  21. Cochran SV, Rabinowitz FE. Gender-sensitive recommendations for assessment and treatment of depression in men. Professional Psychology: Research and Practice. 2003 Apr;34(2):132. (Access here)
  22. Werner FM, Covenas R. Classical neurotransmitters and neuropeptides involved in major depression: a review. International Journal of Neuroscience. 2010 May 1;120(7):455-70. (Access here)
  23. Taylor WD. Depression in the elderly. New England journal of medicine. 2014 Sep 25;371(13):1228-36. (Access here)
  24. Schiepers OJ, Wichers MC, Maes M. Cytokines and major depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2005 Feb 1;29(2):201-17. (Access here)
  25. Zavareh AT, Jomhouri R, Bejestani HS, Arshad M, Daneshmand M, Ziaei H, Babadi N, Amiri M. Depression and hypothyroidism in a population-based study of iranian women. Romanian Journal of Internal Medicine. 2016 Dec 1;54(4):217-21. (Access here)
  26. Dayan CM, Panicker V. Hypothyroidism and depression. European thyroid journal. 2013;2(3):168-79. (Access here)
  27. Ferszt G, Leveillee M. Telling the difference between grief and depression. Lpn. 2009 May 1;5(3):12-3. (Access here)
  28. Boelen PA, van de Schoot R, van den Hout MA, de Keijser J, van den Bout J. Prolonged grief disorder, depression, and posttraumatic stress disorder are distinguishable syndromes. Journal of affective disorders. 2010 Sep 1;125(1-3):374-8. (Access here)
  29. Korczyn AD, Halperin I. Depression and dementia. Journal of the neurological sciences. 2009 Aug 15;283(1-2):139-42. (Access here)
  30. Braverman PK. Premenstrual syndrome and premenstrual dysphoric disorder. Journal of pediatric and adolescent gynecology. 2007 Feb 1;20(1):3-12. (Access here)
  31. Muñoz RF, Beardslee WR, Leykin Y. Major depression can be prevented. American Psychologist. 2012 May;67(4):285. (Access here)
  32. Dunn BD, Roberts H. Improving the capacity to treat depression using talking therapies: Setting a positive clinical psychology agenda. (Access here)
  33. Lisanby SH. Electroconvulsive therapy for depression. New England Journal of Medicine. 2007 Nov 8;357(19):1939-45. (Access here)

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